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鱼油:永葆青春的不老药

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生物老化研究的最新结果表明,鱼油也许是永葆青春的不老神药。研究人员指出,鱼油中所含的ω-3脂肪酸可保护基因“保险丝”,而该“保险丝”决定了细胞寿命的长短。
Fish oil may be the true elixir of youth, according to new evidence of itseffect on biological ageing. Omega-3 fattyacids from fish oil preserve the genetic "fuse" that determines thelifespan of cells, say scientists.
这项针对心脏病患者的研究结果,也许能解释ω-3脂肪酸为何对健康有诸多益处。
The discovery, made in heart disease patients, may explain many of theclaimed health benefits of omega-3.
据称,服用鱼油可以预防心脏病、提高心脏病患者的存活率、减缓老年人智力减退、并有助于防止因年龄增长而导致的眼睛变化,而该变化有可能致盲。还有研究显示,啮齿类动物在食用富含鱼源性ω-3脂肪酸饮食的情况下,寿命增加了三分之一。
Taking fish oil supplements is said to protect against heart disease,improve survival rates after a heart attack, reduce mental decline in old ageand help to prevent age-related changes in the eye that can lead to blindness.Research has also shown that rodents live one-third longer when given a dietenriched with fish-derived omega-3.
尽管ω-3脂肪酸有强大的抗炎特性并能减少血液中某些脂肪的含量,但这些作用的机理却不为人知。这项最新研究显示,ω-3脂肪酸能直接减缓生物衰老过程,这一作用是通过减缓染色体顶端保护帽变短的速度而实现的。
Although omega-3 fatty acids have powerful anti-inflammatory propertiesand lower levels of some blood fats, the mechanisms behind these effects arepoorly understood. The new research suggests that omega-3 has a direct effecton biological ageing by slowing down the rate at which protective caps on theends of chromosomes shorten.
这些被称为“端粒”的保护帽由DNA复制链组成,其保护作用类似于书挡或鞋带的塑料头。这些保护帽能防止染色体(即细胞核中的DNA包)端部受损,并保持染色体中的DNA井然有序。
The caps, called telomeres, are made from copied strands of DNA and have asimilar function to bookends or the plastic ends of shoelaces. They prevent theends of chromosomes – the "packages" of DNA in the cell nucleus –becoming damaged and keep the DNA organised and contained.
细胞每次分裂时,在达到某个临界点前,其端粒会变短。到达该临界点时,DNA就会受损,细胞停止分裂,也许还会死亡。端粒就是以这种方式扮演着生物保险丝的角色。
Each time a cell divides, its telomeres get shorter until a critical pointis reached. DNA then becomes damaged and the cell stops dividing, and may die.In this way, the telomere acts like a biological fuse.
生物保险丝“烧断”的速度因人、因细胞不同而有所变化。人们认为这对老年病有影响。
The rate at which the fuse "burns" can vary both betweenindividual people and individual cells. This is believed to have an impact onage-related diseases.
从事此项研究的美国科学家研究了ω-3脂肪酸对608位门诊心脏病患者的作用。在研究开始时,研究人员测量了这些病人的白细胞染色体端粒长度,并记录了病人血液中两种鱼源性ω-3脂肪酸——DHA和EPA的含量。
US scientists conducting the research looked at the effect of omega-3fatty acids on telomere shortening in 608 hospital out-patients with heartdisease. At the start of the study, measurements were taken of the length ofchromosomal telomeres in the patients' white blood cells. Blood levels of thetwo fish-derived omega-3 fatty acids docosahexaenoic acid (DHA) andeicosapentaenoic acid (EPA) were also measured.
五年后,研究人员又进行了同样的测量。结果显示,染色体端粒缩短速度与ω-3脂肪酸的摄入明显相关。ω-3脂肪酸摄入量最少的病人,其端粒缩短速度最快,而摄入量最高的25%的患者,其端粒缩短速度最慢。
The tests were carried out again after five years, and showed a clearcorrelation with omega-3 intake. Patients consuming the least omega-3 had thefastest rate of telomere shortening, while those in the top 25% of consumptionlevels had the slowest rate.
由加州大学圣地亚哥校区Ramin Farzaneh-Far博士领导的研究小组在《美国医学学会杂志》中发表的文章中写道:“当前的研究表明,鱼源性ω-3脂肪酸是一种潜在的减缓染色体端粒消耗的新方法。
The scientists, led by Dr Ramin Farzaneh-Far of the University ofCalifornia at San Francisco, wrote in theJournal of the American Medical Association: "The present findingsidentify deceleration of telomere attrition as a potentially novel pathway forthe anti-ageing effects of marine omega-3 fatty acids.
“概括起来,在五年的研究期间,稳定性冠状动脉疾病患者血液中鱼源性ω-3脂肪酸基线含量与染色体端粒缩短速度成反比……这些发现使得ω-3脂肪酸用于冠心病患者抗细胞衰老更具潜力。”
"In summary, among patients with stable coronary artery disease,there was an inverse relationship between baseline blood levels of marineomega-3 fatty acids and the rate of telomere shortening over five years ...These findings raise the possibility that omega-3 fatty acids may protectagainst cellular ageing in patients with coronary heart disease. "
标签:鱼油
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2010-01-31 22:28 编辑:kuaileyingyu
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