The journal Science chose an AIDS study as the twenty-eleven "Breakthrough of the Year." The study found that antiretroviral drugs can greatly lower the risk of spreading HIV, the virus that causes AIDS. It showed that infected people with early treatment were ninety-six percent less likely to infect their partners.
The study was a clinical trial known as HPTN 052. Myron Cohen led an international team that began the study in two thousand seven and announced the results last May. But Dr. Cohen says the work really began twenty years ago.
MYRON COHEN: "We had a strong suspicion based on all the biological studies we had done that when we treat people and lower the concentration of HIV in the blood and secretions, we were rendering them less contagious. But we didn't understand the magnitude of the benefit. It blows a gigantic wind behind the idea that treatment will serve as prevention."
Dr. Cohen is director of the Institute for Global Health and Infectious Diseases at the University of North Carolina at Chapel Hill. The National Institute of Allergy and Infectious Diseases paid for the study.
The study involved heterosexual couples in nine countries in Africa, Asia and the Americas. The results have already had an effect on government policies. Those changes include treating HIV-infected people when their immune systems are still relatively healthy.
MYRON COHEN: "This particular 052 study in the last six months has generated policy changes at the level of the United States and the World Health Organization and UNAIDS. And it's inspired new community-based clinical trials that are just about to be launched that apply the scientific discovery. So when you do a single study and it receives so much recognition, and then seems to inform policy in a dramatic way, you think, OK, this was twenty years well-spent."
Dr. Cohen says the study results will be wasted unless they are linked to other areas of HIV treatment and prevention.
MYRON COHEN: "So the 052 study kind of lends itself to understanding that if we don't know who's positive and negative, there's no benefit. If people aren't linked to care, there's no benefit. If they aren't provided drugs, there's no benefit. If they receive the drugs but don't take the pills, there's no benefit. So this cascade is now the focus of our attention."
AIDS activist Mitchell Warren was among those who welcomed the results.
MITCHELL WARREN: "Treatment is prevention. And that becomes a fundamentally different conversation because for many years debates have waged whether we should do treatment or prevention. And the results of the HPTN 052 study actually affirm once and for all that treatment is prevention."
Science also recognized nine other scientific developments last year. You can find the list at 51voa.com. They include progress on a malaria vaccine and research on the DNA of our ancient ancestors. They also include a study of cells that have stopped dividing. It found that clearing them from the bodies of mice can delay some of the effects of aging.
这项临床试验研究被称为HPTN 052，2007年Myron Cohen带领一个国际小组开始了此项研究，并于去年五月宣布了研究结果。但Cohen说真正的研究工作其实20年前就开始了。
Mitchell Warren：“治疗就是预防，这就成了根本上不同的对话，因为多年来都在争论到底该治疗还是预防，HPTN 052研究得出了这样彻底的结果，那就是，治疗即预防。”