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科学家绘制出115岁妇女全套基因序列 探索长寿之谜

所属:社会热点 来源:BBC 阅读:2084 次 评论:1 条 [我要评论]  [+我要收藏]

小编摘要:一个妇女活到115岁离世,死前仍保持年轻心态,毫无老年痴呆或心脏疾病,难怪会引起科学家的好奇。长寿秘密的探索随着她基因序列的绘制完成相信又将进入一个崭新的阶段。

导读:科学家绘制出了一名115岁寿寝的妇女的全套基因序列。荷兰专家称,该妇女去世时是世界上最年老的人,但是心态却年轻好几十岁,并且也没有老年痴呆的迹象。一科学会议上的研究表明该妇女的基因中有抗痴呆的密码。英国科学家称,拥有长寿基因的原因还需要进一步的研究。

人类基因密码首次绘制发生在10多年前。之后随着解读DNA的技术日益先进和廉价,已有几百人的基因图被全套绘制出来。这名115岁妇女的身份未确定,但是至今为止被绘制基因序列的人中年龄最大的。

据悉,该妇女是早产儿,但却过完了长寿而健康的一生。她100岁时曾动过乳腺癌手术,105岁进疗养院,最终死于胃癌。113岁时智力检测相当于60-75岁妇女的水平。死后尸检也未发现老年痴呆的迹象或是任何心脏疾病中的动脉硬化现象。

The woman had some rare genetic changes

The entire DNA sequence of a woman who lived to 115 has been pieced together by scientists.

The woman, who was the oldest in the world at the time of her death, had the mind of someone decades younger and no signs of dementia, say Dutch experts.

The study, reported at a scientific conference in Canada, suggests she had genes that protected against dementia.

Further work could give clues to why some people are born with genes for a long life, says a UK scientist.

It is more than 10 years since the first draft of the human genetic code was revealed.

Since then, perhaps a few hundred individuals have had their genes mapped in full, as the technology to "read" DNA gets better and cheaper.

The woman, whose identity is being kept secret, and is known only as W115, is the oldest person to have her genes mapped.

She donated her body to medical science, allowing doctors to study her brain and other organs, as well as her entire genetic code.

Dr Henne Holstege, of the Department of Clinical Genetics at the VU University Medical Center in Amsterdam, says she appeared to have some rare genetic changes in her DNA.

It is not yet clear what role they carry out, but it appears there is something in her genes that protects against dementia and other diseases of later life.

Dr Holstege told the BBC: "We know that she's special, we know that her brain had absolutely no signs of Alzheimer's.

"There must be something in her body that is protective against dementia.

"We think that there are genes that may ensure a long life and be protective against Alzheimer's."

Proof of principle

W115 was born prematurely and was not expected to survive.

But she lived a long and healthy life, and entered a care home at the age of 105.

She eventually died from a stomach tumour, having been treated for breast cancer at the age of 100.

A test of her mental skills at the age of 113 showed she had the performance of a woman aged 60-75 years.

At post-mortem examination, doctors found no evidence of dementia or the furring of the arteries seen in heart disease.

They are making her gene sequence available to other researchers, to further the cause of science.

The work, which has yet to be published, was presented at the American Society of Human Genetics annual meeting in Montreal, Canada.

Commenting on the study, Dr Jeffrey Barrett, of the Sanger Centre in Cambridge, UK, said it was an important proof of principle.

He told the BBC: "Sequencing the genome of the world's oldest woman is an important starting point to understand how DNA variation relates to the process of having a long, healthy life.

"But in order to really understand the underlying biology of living a long, healthy life, we will need to look at the DNA sequence of hundreds or thousands of people."

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2011-10-17 14:16 编辑:claudiaenglish
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