NEW YORK (AP) -- The biggest question heading into the U.S. Open draw was: Which highly seeded woman could be stuck facing Serena Williams in the third round? The answer: No. 4 Victoria Azarenka of Belarus.
Serena Williams is a three-time U.S. Open champion who leads all active women with 13 Grand Slam titles. Venus Williams is a two-time winner in New York and owns a total of seven major singles trophies.
The Grand Slam tournament starts Monday.
After missing nearly a year of action because of a series of health problems, Serena Williams returned to the tour in June and won two of her four tournaments. She is seeded 28th for the U.S. Open, which followed the rankings rather than taking into account players' past performances.
Venus Williams, meanwhile, is ranked 36th and unseeded; she could face No. 14 Dominika Cibulkova of Slovakia in the third round.
Looking at the latter stages of the men's field, Novak Djokovic and Roger Federer were drawn to possibly meet in one semifinal, while defending champion Rafael Nadal and Andy Murray could meet in the other.
The possible men's quarterfinals are No. 1-seeded Djokovic against No. 7 Gael Monfils; No. 3 Federer against No. 8 Mardy Fish, the highest-seeded American man in New York for the first time; No. 2 Nadal against No. 5 David Ferrer; and No. 4 Murray, who is 0-3 in Grand Slam finals, against No. 6 Robin Soderling, a two-time French Open runner-up.
The women's quarterfinals could be No. 1-seeded Caroline Wozniacki, the 2009 runner-up at the U.S. Open, against reigning French Open champion Li Na; Serena Williams or Azarenka against 2010 French Open champion Francesca Schiavone; 2006 U.S. Open champion Maria Sharapova against the woman who beat her in this year's Wimbledon final, No. 5 Petra Kvitova; and Venus Williams or No. 2 Vera Zvonareva, last year's U.S. Open runner-up, against 2007 Wimbledon finalist Marion Bartoli.